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- 抗原 See all Selenoprotein N (SELENON) products
- Selenoprotein N (SELENON)
- 抗原表位
- AA 135-219
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Selenoprotein N antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB)
- 交叉反应
- 人, 大鼠
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Selenoprotein N protein (135-219AA)
- 亚型
- IgG
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anti-Selenoprotein N (SELENON) antibody
SELENON 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N (SELENON) antibodySELENON 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- Selenoprotein N (SELENON)
- 别名
- SELENON (SELENON 产品)
- 背景
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Background: Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).
Aliases: CFTD antibody, MDRS1 antibody, RSMD1 antibody, RSS antibody, Selenoprotein N antibody, Selenoprotein N, 1 antibody, SelN antibody, SELN_HUMAN antibody, sepn1 antibody
- UniProt
- Q9NZV5
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