CaMKIIbeta/gamma/delta 抗体 (pThr287)
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- 抗原 See all CaMKIIbeta/gamma/delta products
- CaMKIIbeta/gamma/delta
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抗原表位
- AA 230-310, pThr287
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CaMKIIbeta/gamma/delta antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- CaMKIIβ/γ/δ is a protein encoded by the CAMK2B gene which is approximately 72,6 kDa. CaMKIIβ/γ/δ is localised to the cytoplasm. It is involved in RET signalling, post NMDA receptor activation events and cardiac conduction. It is a calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation. It plays a role in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. CaMKIIβ/γ/δ is widely expressed in human tissue including the adult and foetal brain. The CAMK2B gene is associated with Phencyclidine abuse. STJ90941 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous CaMKIIβ/γ/δ protein which only binds about T287 when T287 is phosphorylated.
- 特异性
- Phospho-CaMKIIβ/γ/δ (T287) Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ/δ protein only when phosphorylated at T287.
- 产品特性
- Rabbit polyclonal to Phospho-CaMKIIβ/γ/δ (T287).
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from human CaMKIIbeta/gamma/delta around the phosphorylation site of T287.
- 亚型
- IgG
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- 应用备注
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WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000 - 说明
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Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- 抗原
- CaMKIIbeta/gamma/delta
- Abstract
- CaMKIIbeta/gamma/delta 产品
- 分子量
- 50/65 kDa
- 基因ID
- 816
- UniProt
- Q13554
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