RECQL2 抗体 (Internal Region)
Quick Overview for RECQL2 抗体 (Internal Region) (ABIN6266052)
抗原
See all RECQL2 (WRN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- WRN Antibody detects endogenous levels of total WRN.
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human WRN, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Werner syndrome RecQ like helicase (WRN) (AA 1322-1432) antibody
WRN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C11 unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (Center) antibodyWRN 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) antibodyWRN 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal 195C unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 787-816) antibodyWRN 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB17383 unconjugated
anti-Werner syndrome RecQ like helicase (WRN) antibodyWRN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 1322-1432) antibodyWRN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 1322-1432) antibodyWRN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 1223-1432) antibodyWRN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 794-825), (Middle Region), (Thr802) antibodyWRN 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))
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别名
- WRN
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背景
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Description: Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers, stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation.
Gene: WRN
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分子量
- 162 kDa
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基因ID
- 7486
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UniProt
- Q14191
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途径
- DNA Damage Repair
抗原
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