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- 抗原 See all STT3B 抗体
- STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))
- 抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This STT3B antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- STT3B Antibody detects endogenous levels of total STT3B.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human STT3B, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product STT3B Primary Antibody
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anti-STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B) (AA 682-809) antibody
STT3B 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B) antibodySTT3B 适用: 人 IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))
- 别名
- STT3B (STT3B 产品)
- 别名
- RGD1311563 antibody, 1300006C19Rik antibody, Simp antibody, SIMP antibody, STT3-B antibody, STT3B, catalytic subunit of the oligosaccharyltransferase complex antibody, STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) antibody, Stt3b antibody, STT3B antibody
- 背景
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Description: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.
Gene: STT3B
- 分子量
- 94 kDa
- 基因ID
- 201595
- UniProt
- Q8TCJ2
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