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- 抗原 See all SIRT4 抗体
- SIRT4 (Sirtuin 4 (SIRT4))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIRT4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- SIRT4 Antibody detects endogenous levels of total SIRT4.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SIRT4, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SIRT4 Primary Antibody
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anti-Sirtuin 4 (SIRT4) (AA 28-314) antibody
SIRT4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 51-150) antibodySIRT4 适用: 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 60-255) antibodySIRT4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (C-Term) antibodyVerified SIRT4 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 215-314) antibodySIRT4 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6G6D2 unconjugated
anti-Sirtuin 4 (SIRT4) (Middle Region) antibodySIRT4 适用: 人, 小鼠, 大鼠, Cow, 犬, Pig, 马, 兔, 绵羊, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 29-260) antibodySIRT4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 26-333) antibodySIRT4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sirtuin 4 (SIRT4) (AA 215-314) antibodySIRT4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Sirtuin 4 (SIRT4) (AA 216-265) antibodySIRT4 适用: 人, 犬, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SIRT4 (Sirtuin 4 (SIRT4))
- 别名
- SIRT4 (SIRT4 产品)
- 别名
- SIRT4 antibody, im:7139453 antibody, SIR2L4 antibody, 4930596O17Rik antibody, sirtuin 4 antibody, SIRT4 antibody, sirt4 antibody, Sirt4 antibody
- 背景
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Description: Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Does not seem to deacetylate PC (PubMed:23438705). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD+ levels (PubMed:24043310). Down-regulates insulin secretion.
Gene: SIRT4
- 分子量
- 35 kDa
- 基因ID
- 23409
- UniProt
- Q9Y6E7
- 途径
- Negative Regulation of Hormone Secretion
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