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- 抗原 See all SIK1 抗体
- SIK1 (Salt-Inducible Kinase 1 (SIK1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- SIK Antibody detects endogenous levels of total SIK.
- 预测反应
- Pig,Zebrafish,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human SIK, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product SIK1 Primary Antibody
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anti-Salt-Inducible Kinase 1 (SIK1) (AA 1-783) antibody
SIK1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (AA 1-100) antibodySIK1 适用: 人 ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C12 unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (AA 492-750) antibodySIK1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (AA 567-597), (C-Term) antibodySIK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB3576 unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (AA 1-783) antibodySIK1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (N-Term) antibodySIK1 适用: 人, 马, Cow, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (AA 1-101) antibodySIK1 适用: 人 ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2C12 unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (N-Term) antibodySIK1 适用: 人, 小鼠, 大鼠, 马, 犬, 豚鼠, Cow, Pig, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (AA 51-150) antibodySIK1 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Salt-Inducible Kinase 1 (SIK1) (Tyr86) antibodySIK1 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- SIK1 (Salt-Inducible Kinase 1 (SIK1))
- 别名
- SIK1 (SIK1 产品)
- 别名
- Msk antibody, Sik antibody, Snf1lk antibody, SIK2 antibody, SNF1LK antibody, MSK antibody, SIK antibody, salt-inducible kinase 1 antibody, salt inducible kinase 1 antibody, SIK1 antibody, Sik1 antibody
- 背景
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Description: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction, represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1 (By similarity).
Gene: SIK1
- 分子量
- 85kDa
- 基因ID
- 102724428, 150094
- UniProt
- P57059
- 途径
- Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process
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