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- 抗原 See all PLK4 抗体
- PLK4 (Polo-Like Kinase 4 (PLK4))
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PLK4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- PLK4 Antibody detects endogenous levels of total PLK4
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PLK4
- 亚型
- IgG
- Top Product
- Discover our top product PLK4 Primary Antibody
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anti-Polo-Like Kinase 4 (PLK4) (N-Term) antibody
Verified PLK4 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 1-110) antibodyPLK4 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1C8 unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 724-758) antibodyPLK4 适用: 人 WB 宿主: 兔 Polyclonal RB53118 unconjugated
anti-Polo-Like Kinase 4 (PLK4) antibodyPLK4 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 1-970) antibodyPLK4 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 1-970) antibodyPLK4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Polo-Like Kinase 4 (PLK4) (AA 641-970) antibodyPLK4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
- 有效期
- 12 months
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- 抗原
- PLK4 (Polo-Like Kinase 4 (PLK4))
- 别名
- PLK4 (PLK4 产品)
- 别名
- CG7186 antibody, DmSAK antibody, Dmel\\CG7186 antibody, PLK4 antibody, Plk4 antibody, SAK/PLK antibody, SAK/PLK4 antibody, Sak antibody, plk4 antibody, sak antibody, SAK antibody, STK18 antibody, 1700028H20 antibody, AI385771 antibody, Stk18 antibody, PLK-4 antibody, stk18 antibody, wu:fi33g07 antibody, Sak kinase antibody, polo like kinase 4 antibody, polo-like kinase 4 antibody, polo-like kinase 4 (Drosophila) antibody, serine/threonine-protein kinase PLK4 antibody, SAK antibody, PLK4 antibody, Plk4 antibody, plk4 antibody, LOC5571876 antibody
- 物质类
- Phage Protein
- 背景
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Description: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
Gene: PLK4
- 分子量
- 95 kDa
- 基因ID
- 10733
- UniProt
- O00444
- 途径
- M Phase
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