OPA1 抗体 (Internal Region)
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- 抗原 See all OPA1 抗体
- OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This OPA1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- OPA1 Antibody detects endogenous levels of total OPA1.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human OPA1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product OPA1 Primary Antibody
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anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 661-960) antibody
OPA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 851-960) antibodyOPA1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 8A20 unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 919-955), (C-Term) antibodyOPA1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 651-750) antibodyOPA1 适用: 人, 小鼠, 大鼠, 小鸡, 兔 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 183-418) antibodyOPA1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 1-960) antibodyOPA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 1-960) antibodyOPA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 500-600) antibodyOPA1 适用: 人, 小鼠, 大鼠, 小鸡, 斑马鱼, 灵长类 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Optic Atrophy 1 (Autosomal Dominant) (OPA1) (AA 183-351) antibodyOPA1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))
- 别名
- OPA1 (OPA1 产品)
- 别名
- 1200011N24Rik antibody, AI225888 antibody, AI847218 antibody, lilr3 antibody, mKIAA0567 antibody, MGM1 antibody, NPG antibody, NTG antibody, largeG antibody, fk62d06 antibody, wu:fb77a10 antibody, wu:fk62d06 antibody, zgc:92092 antibody, OPA1, mitochondrial dynamin like GTPase antibody, optic atrophy 1 (autosomal dominant) antibody, Opa1 antibody, OPA1 antibody, opa1 antibody
- 背景
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Description: Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225). Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (PubMed:17709429). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (PubMed:20185555). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space (By similarity). Plays a role in mitochondrial genome maintenance (PubMed:20974897, PubMed:18158317).
Gene: OPA1
- 分子量
- 111 kDa
- 基因ID
- 4976
- UniProt
- O60313
- 途径
- Tube Formation
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