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- 抗原 See all NSMCE2 抗体
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NSMCE2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- NSMCE2 Antibody detects endogenous levels of total NSMCE2.
- 预测反应
- Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human NSMCE2, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product NSMCE2 Primary Antibody
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anti-E3 SUMO-Protein Ligase NSE2 (NSMCE2) (AA 1-247) antibody
NSMCE2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-E3 SUMO-Protein Ligase NSE2 (NSMCE2) (AA 1-247) antibodyNSMCE2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 SUMO-Protein Ligase NSE2 (NSMCE2) (N-Term) antibodyNSMCE2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-E3 SUMO-Protein Ligase NSE2 (NSMCE2) (AA 107-156) antibodyNSMCE2 适用: 人, 兔, 马, Cow, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))
- 别名
- NSMCE2 (NSMCE2 产品)
- 别名
- 1110014D18Rik antibody, AI661537 antibody, RGD1305156 antibody, C8orf36 antibody, MMS21 antibody, NSE2 antibody, ZMIZ7 antibody, Non-SMC element 2 antibody, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase antibody, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog antibody, Smc5-6 complex non-SMC subunit 2 antibody, Nsmce2 antibody, NSMCE2 antibody, nsmce2.L antibody, nse2 antibody
- 背景
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Description: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.
Gene: NSMCE2
- 分子量
- 28 kDa
- 基因ID
- 286053
- UniProt
- Q96MF7
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