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Ki-67 抗体 (Internal Region)

MKI67 适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6262794
发货至: 中国
  • 抗原 See all Ki-67 (MKI67) 抗体
    Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
    抗原表位
    • 16
    • 16
    • 16
    • 16
    • 15
    • 15
    • 12
    • 8
    • 7
    • 7
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 197
    • 86
    • 59
    • 16
    • 15
    • 5
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 160
    • 40
    • 4
    • 3
    克隆类型
    • 151
    • 54
    多克隆
    标记
    • 92
    • 14
    • 14
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    This Ki-67 antibody is un-conjugated
    应用范围
    • 87
    • 76
    • 67
    • 65
    • 55
    • 50
    • 43
    • 32
    • 30
    • 14
    • 13
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Ki67 Antibody detects endogenous levels of total Ki67.
    预测反应
    Bovine,Rabbit,Dog
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human Ki67, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product MKI67 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • Liu, Huang, Jin, Zhou, Chen, Li, Chen, Li, Yao, Li, Lan, Ye, Wang: "MicroRNA-370 inhibits the growth and metastasis of lung cancer by down-regulating epidermal growth factor receptor expression." in: Oncotarget, Vol. 8, Issue 50, pp. 88139-88151, (2018) (PubMed).

    Yang, Ren, Zhang, Li, Cheng, Xia: "Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway." in: Biomedicine & pharmacotherapy, Vol. 100, pp. 226-232, (2018) (PubMed).

    Gong, Fan, Wang, Han, Lv, Xu, Chen, He: "Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis." in: World journal of gastroenterology, Vol. 24, Issue 16, pp. 1766-1778, (2018) (PubMed).

    Zhu, Cai, Guo, Chen, Yi, Zhao, Cai, Wang: "Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression." in: Tumour biology, Vol. 37, Issue 10, pp. 14009-14023, (2017) (PubMed).

    Sun, Huang, Li, Yang, Xi, Wang, Zhang, Fu, Li: "Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development." in: Oncotarget, Vol. 7, Issue 7, pp. 8341-59, (2016) (PubMed).

    Chen, Liang, Zhu, Fu, Chen, Mo, Zhou, Fu, Bi, He, Yang, Wu, Jiang, Zhong: "CC chemokine ligand 18 correlates with malignant progression of prostate cancer." in: BioMed research international, Vol. 2014, pp. 230183, (2014) (PubMed).

  • 抗原
    Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
    别名
    MKI67 (MKI67 产品)
    别名
    MKI67 antibody, kia antibody, mki67 antibody, MGC132156 antibody, D630048A14Rik antibody, Ki-67 antibody, Ki67 antibody, KIA antibody, MIB-1 antibody, marker of proliferation Ki-67 antibody, marker of proliferation Ki-67 L homeolog antibody, marker of proliferation Ki-67 S homeolog antibody, antigen identified by monoclonal antibody Ki 67 antibody, antigen identified by monoclonal antibody Ki-67 antibody, nucleolar protein interacting with the FHA domain of MKI67 antibody, MKI67 antibody, mki67 antibody, mki67.L antibody, mki67.S antibody, Mki67 antibody, NIFK antibody
    背景

    Description: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

    Gene: MKI67

    分子量
    358kDa
    基因ID
    4288
    UniProt
    P46013
    途径
    Glycosaminoglycan Metabolic Process
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