Ki-67 抗体 (Internal Region)
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- 抗原 See all Ki-67 (MKI67) 抗体
- Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Ki-67 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Ki67 Antibody detects endogenous levels of total Ki67.
- 预测反应
- Bovine,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human Ki67, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product MKI67 Primary Antibody
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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MicroRNA-370 inhibits the growth and metastasis of lung cancer by down-regulating epidermal growth factor receptor expression." in: Oncotarget, Vol. 8, Issue 50, pp. 88139-88151, (2018) (PubMed).
: "Oridonin inhibits oral cancer growth and PI3K/Akt signaling pathway." in: Biomedicine & pharmacotherapy, Vol. 100, pp. 226-232, (2018) (PubMed).
: "Mucosa repair mechanisms of Tong-Xie-Yao-Fang mediated by CRH-R2 in murine, dextran sulfate sodium-induced colitis." in: World journal of gastroenterology, Vol. 24, Issue 16, pp. 1766-1778, (2018) (PubMed).
: "Depletion of Dicer promotes epithelial ovarian cancer progression by elevating PDIA3 expression." in: Tumour biology, Vol. 37, Issue 10, pp. 14009-14023, (2017) (PubMed).
: "Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development." in: Oncotarget, Vol. 7, Issue 7, pp. 8341-59, (2016) (PubMed).
: "CC chemokine ligand 18 correlates with malignant progression of prostate cancer." in: BioMed research international, Vol. 2014, pp. 230183, (2014) (PubMed).
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MicroRNA-370 inhibits the growth and metastasis of lung cancer by down-regulating epidermal growth factor receptor expression." in: Oncotarget, Vol. 8, Issue 50, pp. 88139-88151, (2018) (PubMed).
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- 抗原
- Ki-67 (MKI67) (Antigen Identified By Monoclonal Antibody Ki-67 (MKI67))
- 别名
- MKI67 (MKI67 产品)
- 别名
- MKI67 antibody, kia antibody, mki67 antibody, MGC132156 antibody, D630048A14Rik antibody, Ki-67 antibody, Ki67 antibody, KIA antibody, MIB-1 antibody, marker of proliferation Ki-67 antibody, marker of proliferation Ki-67 L homeolog antibody, marker of proliferation Ki-67 S homeolog antibody, antigen identified by monoclonal antibody Ki 67 antibody, antigen identified by monoclonal antibody Ki-67 antibody, nucleolar protein interacting with the FHA domain of MKI67 antibody, MKI67 antibody, mki67 antibody, mki67.L antibody, mki67.S antibody, Mki67 antibody, NIFK antibody
- 背景
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Description: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
Gene: MKI67
- 分子量
- 358kDa
- 基因ID
- 4288
- UniProt
- P46013
- 途径
- Glycosaminoglycan Metabolic Process
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