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- 抗原 See all KCND2 抗体
- KCND2 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2))
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抗原表位
- C-Term
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KCND2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- Kv4.2/KCND2 Antibody detects endogenous levels of total Kv4.2/KCND2.
- 预测反应
- Bovine,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human Kv4.2/KCND2, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product KCND2 Primary Antibody
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anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) (AA 27-184) antibody
KCND2 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 5B11B9 unconjugated
anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) (AA 432-481) antibodyKCND2 适用: 人, 大鼠, 小鼠, 兔, 猴, Pig, 小鸡, Cow WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) (AA 454-469), (C-Term), (Intracellular) antibodyKCND2 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 豚鼠 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) (AA 501-630) antibodyKCND2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) (AA 501-630) antibodyKCND2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) antibodyKCND2 适用: 人, 小鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) (AA 123-151), (N-Term) antibodyKCND2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2) (AA 122-151), (N-Term) antibodyKCND2 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- KCND2 (Potassium Voltage-Gated Channel, Shal-Related Subfamily, Member 2 (KCND2))
- 别名
- KCND2 (KCND2 产品)
- 别名
- KCND2 antibody, si:dkey-24j9.3 antibody, si:dkeyp-97c5.3 antibody, DKFZp459P1550 antibody, AI839615 antibody, AW555701 antibody, Kv4.2 antibody, R75121 antibody, mKIAA1044 antibody, KV4.2 antibody, RK5 antibody, Shal1 antibody, potassium voltage-gated channel subfamily D member 2 antibody, potassium voltage-gated channel, Shal-related subfamily, member 2 antibody, potassium voltage-gated channel, Shal-related family, member 2 antibody, KCND2 antibody, kcnd2 antibody, Kcnd2 antibody, LOC101669961 antibody
- 背景
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Description: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10551270, PubMed:15454437, PubMed:14695263, PubMed:14623880, PubMed:14980201, PubMed:16934482, PubMed:24811166, PubMed:24501278). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:11507158). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCND2 and KCND3, channel properties depend on the type of pore-forming alpha subunits that are part of the channel. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases channel activity, it modulates the kinetics of channel activation and inactivation, shifts the threshold for channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed:15454437, PubMed:14623880, PubMed:14980201, PubMed:19171772, PubMed:24501278, PubMed:24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both channel characteristics and activity (By similarity).
Gene: KCND2
- 分子量
- 71kDa
- 基因ID
- 3751
- UniProt
- Q9NZV8
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