Ephrin A1 抗体 (Internal Region)
Quick Overview for Ephrin A1 抗体 (Internal Region) (ABIN6261448)
抗原
See all Ephrin A1 (EFNA1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- EFNA1 Antibody detects endogenous levels of total EFNA1.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human EFNA1, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Ephrin A1 (EFNA1) antibody
EFNA1 适用: 人, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 19-182) antibodyEFNA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) antibodyEFNA1 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 150-164), (Extracellular) antibodyEFNA1 适用: 人 WB, IF, FACS, IC, LCI 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 19-182) antibodyEFNA1 适用: 人 ELISA, WB, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 19-182) antibodyEFNA1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) antibodyEFNA1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (Internal Region) antibodyEFNA1 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 101-205) antibodyEFNA1 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 1-205) antibodyEFNA1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- Ephrin A1 (EFNA1)
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别名
- EFNA1
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背景
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Description: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Gene: EFNA1
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分子量
- 24kDa
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基因ID
- 1942
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UniProt
- P20827
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途径
- RTK signaling
抗原
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