Ephrin A1 抗体 (Extracellular)
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Quick Overview for Ephrin A1 抗体 (Extracellular) (ABIN7043128)
抗原
See all Ephrin A1 (EFNA1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 150-164, Extracellular
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原理
- A Rabbit Polyclonal Antibody to Ephrin-A1
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Mouse,rat - 13,15 amino acid residues identical
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产品特性
- Anti-Ephrin-A1 (extracellular) Antibody is directed against an extracellular epitope of human Ephrin-A1. Anti-Ephrin-A1 (extracellular) Antibody (ABIN7043128, ABIN7044255 and ABIN7044256) can be used in western blot and live cell imaging applications. The antibody recognizes an extracellular epitope and thus is ideal for detecting Ephrin-A1 in living cells. It has been designed to recognize Ephrin-A1 from human, rat and mouse samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- (C)KITHSPQAHDNPQEK, corresponding to amino acid residues 150-164 of human Ephrin-A1
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亚型
- IgG
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anti-Ephrin A1 (EFNA1) (Internal Region) antibody
EFNA1 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 19-182) antibodyEFNA1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) antibodyEFNA1 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 19-182) antibodyEFNA1 适用: 人 ELISA, WB, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 19-182) antibodyEFNA1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) antibodyKD Validated EFNA1 适用: 人 WB 宿主: 兔 Monoclonal 23GB5265 unconjugated Recombinant Antibody
anti-Ephrin A1 (EFNA1) (Internal Region) antibodyEFNA1 适用: 人, 大鼠, 小鼠 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) antibodyEFNA1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (AA 101-205) antibodyEFNA1 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Ephrin A1 (EFNA1) (Internal Region) antibodyVerified EFNA1 适用: 大鼠, 小鼠 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
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应用备注
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WB: 1:200-1:400
FC: 5 μg per reaction
ICC: 1:50
IHC: The optimal concentration should be determined by the user
IP: The optimal concentration should be determined by the user
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说明
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Negative Control: (ABIN7235302)
Blocking Peptide: (ABIN7235302)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- Ephrin A1 (EFNA1)
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别名
- EFNA1
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背景
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Synonyms: EPH-related receptor tyrosine kinase ligand 1, LERK1, EFNA1
Description: Ephrin-A1, a ligand of type-A Eph receptor tyrosine kinases and the Eph/ephrin system, has been shown to play important roles in the nervous system, tissue patterning and cell adhesion through receptor-ligand interactions and intracellular signaling1. Ephrins can be divided into two subclasses: ephrin A and ephrin B. Ephrin A ligands (ephrin A1-A5) are anchored to the cell surface via a glycosylphosphatidylinositol (GPI) anchor and bind to Eph A receptors (Eph A1-A8), whereas ephrin B ligands (ephrin B1-B3) have transmembrane and cytoplasmic domains and interact with Eph B receptors (Eph B1-B6)2.Eph receptors and ephrins are highly expressed in the brain and in the developing nervous system, where they have well-known roles in the establishment of neuronal connectivity by guiding axons to the appropriate targets and regulating the formation of synaptic connections. Ephrins are expressed in numerous regions of the vertebrate embryo including the ectoderm, mesoderm, and endoderm3.Ephrin (Eph) receptors are frequently overexpressed in a variety of human malignant tumors, and are associated with tumor growth, invasion, metastasis and angiogenesis. Recent studies using clinical samples showed that ephrin-A1 expression was up-regulated in colorectal cancer and hepatocellular carcinoma and positively correlated with a poor prognostic value4.
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基因ID
- 1942
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NCBI登录号
- NM_004428
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UniProt
- P20827
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途径
- RTK signaling
抗原
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