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- 抗原 See all DDIT4 抗体
- DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
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抗原表位
- Internal Region
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DDIT4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- DDIT4 Antibody detects endogenous levels of total DDIT4.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human DDIT4, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product DDIT4 Primary Antibody
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anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 20-49), (N-Term) antibody
DDIT4 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB12592 unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 1-232) antibodyDDIT4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 198-227), (C-Term) antibodyDDIT4 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB11618 unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (N-Term) antibodyDDIT4 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 1-232) antibodyDDIT4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 45-94) antibodyDDIT4 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (pThr23), (pThr25) antibodyDDIT4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (C-Term), (N-Term) antibodyDDIT4 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
- 别名
- DDIT4 (DDIT4 产品)
- 别名
- redd1 antibody, Dig2 antibody, REDD-1 antibody, REDD1 antibody, 5830413E08Rik antibody, AA415483 antibody, Rtp801 antibody, dig2 antibody, rtp801 antibody, sb:cb821 antibody, zgc:64114 antibody, DNA damage inducible transcript 4 antibody, DNA-damage-inducible transcript 4 antibody, DNA damage inducible transcript 4 S homeolog antibody, ddit4 antibody, DDIT4 antibody, Ddit4 antibody, ddit4.S antibody
- 背景
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Description: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.
Gene: DDIT4
- 分子量
- 25 kDa
- 基因ID
- 54541
- UniProt
- Q9NX09
- 途径
- Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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