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DDIT4 抗体 (AA 1-232)

DDIT4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6139466
发货至: 中国
  • 抗原 See all DDIT4 抗体
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    抗原表位
    • 15
    • 14
    • 13
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 1-232
    适用
    • 53
    • 23
    • 9
    • 2
    • 2
    • 2
    • 2
    • 1
    宿主
    • 64
    • 4
    克隆类型
    • 66
    • 2
    多克隆
    标记
    • 27
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This DDIT4 antibody is un-conjugated
    应用范围
    • 45
    • 33
    • 26
    • 13
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunofluorescence (IF)
    序列
    MPSLWDRFSS SSTSSSPSSL PRTPTPDRPP RSAWGSATRE EGFDRSTSLE SSDCESLDSS NSGFGPEEDT AYLDGVSLPD FELLSDPEDE HLCANLMQLL QESLAQARLG SRRPARLLMP SQLVSQVGKE LLRLAYSEPC GLRGALLDVC VEQGKSCHSV GQLALDPSLV PTFQLTLVLR LDSRLWPKIQ GLFSSANSPF LPGFSQSLTL STGFRVIKKK LYSSEQLLIE EC
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human DDIT4 (NP_061931.1).
    亚型
    IgG
    Top Product
    Discover our top product DDIT4 Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    说明

    HIGH QUALITY

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
    别名
    DDIT4 (DDIT4 产品)
    别名
    redd1 antibody, Dig2 antibody, REDD-1 antibody, REDD1 antibody, 5830413E08Rik antibody, AA415483 antibody, Rtp801 antibody, dig2 antibody, rtp801 antibody, sb:cb821 antibody, zgc:64114 antibody, DNA damage inducible transcript 4 antibody, DNA-damage-inducible transcript 4 antibody, DNA damage inducible transcript 4 S homeolog antibody, ddit4 antibody, DDIT4 antibody, Ddit4 antibody, ddit4.S antibody
    背景
    Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1. Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type, it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity. Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.,DDIT4,Dig2,REDD-1,REDD1,Epigenetics & Nuclear Signaling,Cancer,Signal Transduction,mTOR Signaling Pathway,Endocrine & Metabolism,Neuroscience,Neurodegenerative Diseases,Dopamine Signaling in Parkinson's Disease,Neurodegenerative Diseases Markers,Cardiovascular,Hypoxia,Hypoxia-Regulated,DDIT4
    分子量
    25 kDa
    基因ID
    54541
    UniProt
    Q9NX09
    途径
    Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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