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CDK7 抗体 (Internal Region)

Name: CDK7 抗体 (Internal Region)
SKU: ABIN6260718
Availability: OutOfStock

CDK7 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis on HeLa cell lysate using CDK7 Antibody,The lane on the left is treated with the antigen-specific peptide. (CDK7 抗体 (Internal Region))

IF/ICC

ABIN6266648 at 1/100 staining human brain tissue sections by IHC-P. (CDK7 抗体 (Internal Region))

IHC

3 images

产品编号 ABIN6260718

发货至: 中国

Datasheet as PDF

抗原 See all CDK7 抗体

CDK7 (Cyclin-Dependent Kinase 7 (CDK7))
抗原表位
32

12

7

5

4

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
适用
98

29

13

6

5

5

4

4

2

2

2

2

1

1

1
人, 小鼠
宿主
80

19

1
兔
Compatible Secondaries
克隆类型
74

26
多克隆
标记
53

7

5

4

3

3

3

3

3

3

2

2

2

2

1

1

1

1

1
This CDK7 antibody is un-conjugated
应用范围
74

34

33

17

15

14

14

11

8

8

8

6

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

CDK7 Antibody detects endogenous levels of total CDK7.

预测反应

Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human CDK7, corresponding to a region within the internal amino acids.

亚型

IgG

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anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibody
CDK7 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) antibody
CDK7 适用: 人, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibody
CDK7 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) antibody
CDK7 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-346) antibody
CDK7 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) (C-Term) antibody
CDK7 适用: 人, 小鼠, 大鼠, Cow, 马, Pig, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 211-346) antibody
CDK7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) (pThr170) antibody
CDK7 适用: 人, 小鼠 WB, IHC (p), DB 宿主: 兔 Polyclonal RB07518 unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) (C-Term) antibody
CDK7 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 7 (CDK7) (AA 1-80) antibody
CDK7 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IHC (fro), IF (p), FACS 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

别名

CDK7 (CDK7 产品)

别名

CAK1 antibody, CDKN7 antibody, HCAK antibody, MO15 antibody, STK1 antibody, p39MO15 antibody, AI323415 antibody, AI528512 antibody, C230069N13 antibody, Cdkn7 antibody, Crk4 antibody, CD 7 antibody, CDK7 antibody, CG3319 antibody, DmCDK7 antibody, DmCdk7 antibody, DmMO15 antibody, DmMo15 antibody, Dmcdk7 antibody, Dmel\\CG3319 antibody, Mo15 antibody, cdk-7 antibody, cdk7 antibody, dCdk7 antibody, p40[MO15] antibody, p40MO15 antibody, stk1 antibody, zgc:85821 antibody, cak1 antibody, cdkn7 antibody, p39mo15 antibody, cyclin dependent kinase 7 antibody, cyclin-dependent kinase 7 antibody, Cyclin-dependent kinase 7 antibody, cyclin-dependent kinase 7 L homeolog antibody, CDK7 antibody, Cdk7 antibody, cdk7.L antibody, cdk7 antibody

背景

Description: Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Phosphorylation of POLR2A in complex with DNA promotes transcription initiation by triggering dissociation from DNA. Its expression and activity are constant throughout the cell cycle. Upon DNA damage, triggers p53/TP53 activation by phosphorylation, but is inactivated in turn by p53/TP53, this feedback loop may lead to an arrest of the cell cycle and of the transcription, helping in cell recovery, or to apoptosis. Required for DNA-bound peptides-mediated transcription and cellular growth inhibition.
Gene: CDK7

分子量

39kDa

基因ID

1022

UniProt

P50613

途径

Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase