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RAGE 抗体 (Internal Region)

Name: RAGE 抗体 (Internal Region)
SKU: ABIN6259820
Availability: OutOfStock

AGER 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

Western blot analysis of AGER（RAGE） expression in HUVEC whole cell lysate. (RAGE 抗体 (Internal Region))

ABIN6268856 at 1/100 staining Human urothelial cancer tissue by IHC-P. (RAGE 抗体 (Internal Region))

IHC

IF/ICC

3 images

(1 reference)

产品编号 ABIN6259820

发货至: 中国

Datasheet as PDF

抗原 See all RAGE (AGER) 抗体

RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
抗原表位
20

16

16

11

11

9

8

7

4

4

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
适用
143

82

64

8

6

5

4

3

2

2

1
人, 小鼠, 大鼠
宿主
137

11

4

2

1
兔
Compatible Secondaries
克隆类型
131

23

1
多克隆
标记
71

11

10

9

8

5

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2
This RAGE antibody is un-conjugated
应用范围
127

66

49

34

27

26

24

11

8

8

7

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

特异性

AGER/RAGE Antibody detects endogenous levels of total AGER/RAGE.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human AGER/RAGE, corresponding to a region within the internal amino acids.

亚型

IgG

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Discover our top product AGER Primary Antibody
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 180-402) antibody
AGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-404) antibody
AGER 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 151-250) antibody
AGER 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IP, IF (cc), ICC, IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-274) antibody
AGER 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) antibody
AGER 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C1 unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-120), (N-Term) antibody
AGER 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 76-104) antibody
AGER 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) antibody
AGER 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (N-Term) antibody
AGER 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (C-Term) antibody
AGER 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Wu, Zheng, Bai, Xia, Zhang, Guo: "HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma." in: OncoTargets and therapy, Vol. 11, pp. 4501-4510, (2018) (PubMed).
抗原

RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

别名

AGER (AGER 产品)

别名

RAGE antibody, AGER antibody, advanced glycosylation end-product specific receptor antibody, advanced glycosylation end product-specific receptor antibody, MAPK/MAK/MRK overlapping kinase antibody, AGER antibody, Ager antibody, LOC719012 antibody

背景

Description: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Gene: AGER

分子量

42 kDa

基因ID

177

UniProt

Q15109

途径

Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins