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RAGE 抗体 (N-Term)

Name: RAGE 抗体 (N-Term)
SKU: ABIN3043529
Availability: OutOfStock

There are 8+ publications for this product available. The 兔多克隆 anti-RAGE antibody is suitable to detect RAGE in samples from 人, 小鼠和大鼠. It has been validated for WB 和 IHC.

Anti- RAGE Picoband antibody, Western blotting All lanes: Anti RAGE at 0. (RAGE 抗体 (N-Term))

Anti- RAGE Picoband antibody, IHC(P) IHC(P): Mouse Lung Tissue (RAGE 抗体 (N-Term))

IHC

Anti- RAGE Picoband antibody, IHC(P) IHC(P): Rat Lung Tissue (RAGE 抗体 (N-Term))

IHC

Anti- RAGE Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue (RAGE 抗体 (N-Term))

IHC

4 images

(8 references)

产品编号 ABIN3043529

发货至: 中国

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Quick Overview for RAGE 抗体 (N-Term) (ABIN3043529)

抗原

See all RAGE (AGER) 抗体

RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This RAGE antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product AGER Primary Antibody

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AA 91-120, N-Term

原理

Anti-RAGE/AGER Antibody

序列

IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-RAGE/AGER Antibody (ABIN3043529). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human RAGE, different from the related mouse and rat sequences by six amino acids.

亚型

IgG
anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-237) antibody
AGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 180-402) antibody
AGER 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-404) antibody
AGER 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 151-250) antibody
AGER 适用: 人, 小鼠, 大鼠 WB, ELISA, IP, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 91-274) antibody
AGER 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) antibody
AGER 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C1 unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 76-104) antibody
AGER 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) antibody (Cy3)
AGER 适用: 人, Cow WB, IHC, ELISA, ICC, IHC (p) 宿主: 小鼠 Monoclonal DD-A11 Cy3

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 43-404) antibody
AGER 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, FACS, IF 宿主: 兔 Polyclonal unconjugated

anti-Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 173-418) antibody
AGER 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Rat

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Li, Lu, Zhang, Zhou, Chen: "Increased Serum High Mobility Group Box 1 (HMGB1) Concentration and the Altered Expression of HMGB1 and Its Receptor Advanced Glycation Endproducts in Pemphigus." in: Annals of dermatology, Vol. 29, Issue 1, pp. 121-123, (2017) (PubMed).

Wang, He, Wang, Yuan, Guo, Chai, Wang, Hu, Zhang: "Neuroprotective effect of salvianolate lyophilized injection against cerebral ischemia in type 1 diabetic rats." in: BMC complementary and alternative medicine, Vol. 17, Issue 1, pp. 258, (2017) (PubMed).

Yang, Gao, Wu, Yu, Li, Meng, Li, Yan, Jin: "Epigallocatechin-3-gallate attenuates neointimal hyperplasia in a rat model of carotid artery injury by inhibition of high mobility group box 1 expression." in: Experimental and therapeutic medicine, Vol. 14, Issue 3, pp. 1975-1982, (2017) (PubMed).

Yu, Yu, Liu, Yu, Liu, Liu, Su, Jiang, Chen: "Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway." in: SpringerPlus, Vol. 5, pp. 215, (2016) (PubMed).

Qin, Niu, Wang, Xu, Qiao, Gu: "Heparanase induced by advanced glycation end products (AGEs) promotes macrophage migration involving RAGE and PI3K/AKT pathway." in: Cardiovascular diabetology, Vol. 12, pp. 37, (2013) (PubMed).

Liu, Wang, Feng, Ma, Fu, Song, Jia, Ma: "Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats." in: Journal of medicinal food, Vol. 16, Issue 7, pp. 577-86, (2013) (PubMed).

Wang, Zhang, Liu, Cui, Yang, Li, Du: "Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia." in: Brain research, Vol. 1321, pp. 143-51, (2010) (PubMed).

Wang, Zhang, Liu, Yang, Cui, Li: "Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kappaB expression." in: Neuroscience letters, Vol. 471, Issue 3, pp. 152-6, (2010) (PubMed).
抗原

RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

别名

AGER

背景

Synonyms: Advanced glycosylation end product-specific receptor,Receptor for advanced glycosylation end products,AGER,RAGE,
Tissue Specificity: Endothelial cells.
Background: The receptor for advanced glycation end products (RAGE) is a multi-ligand member of the immunoglobulin superfamily of cell surface molecules. It interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. RAGE is also a central cell surface receptor for amphoterin and EN-RAGE. And RAGE is associated with sustained NF-kappaB activation in the diabetic microenvironment and has a central role in sensory neuronal dysfunction. Moreover, RAGE propagates cellular dysfunction in several inflammatory disorders and diabetes, and it also functions as an endothelial adhesion receptor promoting leukocyte recruitment.
Sequence Similarities: Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

分子量

45-58 kDa

基因ID

177

UniProt

Q15109

途径

Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins