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RORC 抗体 (Internal Region)

Name: RORC 抗体 (Internal Region)
SKU: ABIN6259177
Availability: OutOfStock

RORC 适用: 人, 小鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts from HuvEc cells, using RORG antibody. (RORC 抗体 (Internal Region))

IF/ICC

2 images

产品编号 ABIN6259177

发货至: 中国

Datasheet as PDF

抗原 See all RORC 抗体

RORC (RAR-Related Orphan Receptor C (RORC))
抗原表位
16

7

7

6

6

6

5

5

4

4

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
适用
97

54

23

9

8

8

6

6

6

4

3

2

1

1

1

1

1

1

1

1
人, 小鼠
宿主
80

17

2

1

1
兔
Compatible Secondaries
克隆类型
83

18
多克隆
标记
53

7

5

5

5

5

2

2

2

2

2

2

2

2

2

1

1

1
This RORC antibody is un-conjugated
应用范围
80

37

24

24

15

13

11

4

4

3

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

特异性

RORG Antibody detects endogenous levels of total RORG.

预测反应

Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human RORG, corresponding to a region within the internal amino acids.

亚型

IgG

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anti-RAR-Related Orphan Receptor C (RORC) (AA 200-212) antibody
Verified RORC 适用: 人 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor C (RORC) (N-Term) antibody
RORC 适用: 人, 小鼠, 大鼠, Cow, 马, 犬, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor C (RORC) (Middle Region) antibody
RORC 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor C (RORC) (AA 110-159) antibody
RORC 适用: 人, Cow, 马, 豚鼠, 猴, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor C (RORC) (AA 412-517) antibody
RORC 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G7 unconjugated

anti-RAR-Related Orphan Receptor C (RORC) (AA 1-50) antibody
RORC 适用: 人, 小鼠 WB, FACS 宿主: 小鼠 Monoclonal 4G419 unconjugated

anti-RAR-Related Orphan Receptor C (RORC) (AA 1-518) antibody
RORC 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor C (RORC) antibody
RORC 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor C (RORC) antibody
RORC 适用: 人 ELISA, Coat 宿主: 小鼠 Monoclonal RORC-2942 unconjugated

应用备注

WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

RORC (RAR-Related Orphan Receptor C (RORC))

别名

RORC (RORC 产品)

别名

NR1F3 antibody, RORG antibody, RZR-GAMMA antibody, RZRG antibody, TOR antibody, Nr1f3 antibody, RORgamma antibody, Thor antibody, RAR related orphan receptor C antibody, RAR-related orphan receptor C antibody, RAR-related orphan receptor gamma antibody, RORC antibody, Rorc antibody

背景

Description: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376).
Gene: RORC

分子量

58 kDa

基因ID

6097

UniProt

P51449

途径

Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway