JNK2 抗体 (N-Term)
Quick Overview for JNK2 抗体 (N-Term) (ABIN6257974)
抗原
See all JNK2 (MAPK9) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- JNK2 Antibody detects endogenous levels of total JNK2.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human MAPK9, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 321-424) antibody
MAPK9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 321-424) antibodyMAPK9 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2F8 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibodyMAPK9 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1C1-3A8 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibodyMAPK9 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2G3 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 227-382) antibodyMAPK9 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2F6H11 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 130-387) antibodyMAPK9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibodyMAPK9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibodyMAPK9 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 349-379), (C-Term) antibodyMAPK9 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2510 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibodyMAPK9 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))
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别名
- MAPK9
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背景
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Description: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692).
Gene: MAPK9
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分子量
- 48 kDa
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基因ID
- 5601
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UniProt
- P45984
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途径
- MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins
抗原
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