AAK1 抗体 (Internal Region)
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- 抗原 See all AAK1 抗体
- AAK1 (AP2 associated kinase 1 (AAK1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AAK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- AAK1 Antibody detects endogenous levels of total AAK1.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human AAK1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product AAK1 Primary Antibody
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anti-AP2 associated kinase 1 (AAK1) (AA 315-415) antibody
AAK1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4B10 unconjugated
anti-AP2 associated kinase 1 (AAK1) (AA 274-465) antibodyAAK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (C-Term) antibodyAAK1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (N-Term) antibodyAAK1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (AA 301-400) antibodyAAK1 适用: 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (N-Term) antibodyAAK1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) antibodyAAK1 适用: 人, 小鼠, 大鼠, Cow WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (Internal Region) antibodyAAK1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (Internal Region) antibodyVerified AAK1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-AP2 associated kinase 1 (AAK1) (AA 593-642) antibodyAAK1 适用: 人, 小鼠, 大鼠, 马, 猴, 兔, 犬, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- AAK1 (AP2 associated kinase 1 (AAK1))
- 别名
- AAK1 (AAK1 产品)
- 别名
- 5530400K14Rik antibody, 9630042K20 antibody, AU067724 antibody, AU067726 antibody, BC028270 antibody, C79663 antibody, D6Ertd245e antibody, R75501 antibody, mKIAA1048 antibody, RGD1563580 antibody, aak1 antibody, si:dkey-261l11.5 antibody, AP2 associated kinase 1 antibody, uncharacterized protein FLJ45252 antibody, AP2 associated kinase 1b antibody, AAK1 antibody, Aak1 antibody, LOC100512341 antibody, aak1b antibody
- 背景
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Description: Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1, increases its localization in endosomes and regulates its transcriptional activity.
Gene: AAK1
- 分子量
- 94 kDa
- 基因ID
- 22848
- UniProt
- Q2M2I8
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