ROS1 抗体
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北京 101111
Quick Overview for ROS1 抗体 (ABIN6243980)
抗原
See all ROS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
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免疫原
- This ROS1 antibody is generated from a mouse immunized with a recombinant protein of human ROS1.
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亚型
- IgG1 kappa
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应用备注
- IHC: 1:250. WB: 1:4000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))
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别名
- ROS1
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背景
- Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
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分子量
- 263915
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UniProt
- P08922
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途径
- RTK signaling
抗原
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