FGFR1 抗体 (AA 291-324)
(1 reference)Quick Overview for FGFR1 抗体 (AA 291-324) (ABIN6243223)
抗原
See all FGFR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 291-324
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预测反应
- C, Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This FGFR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 291-324 amino acids from the Central region of human FGFR1.
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亚型
- Ig Fraction
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anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 19-48), (N-Term) antibody
FGFR1 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB04521 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 236-362) antibodyFGFR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (C-Term) antibodyFGFR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 19-48) antibodyFGFR1 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 31-150) antibodyFGFR1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 5E9 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (pTyr766) antibodyFGFR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (Tyr766) antibodyFGFR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 806-842), (C-Term) antibodyFGFR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1440CT772-50-23 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) antibodyFGFR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C3 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 22-96) antibodyFGFR1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. FC: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium." in: PLoS ONE, Vol. 12, Issue 8, pp. e0183181, (2017) (PubMed).
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: "Fibroblast growth factor receptor-1 mediates internalization of pathogenic spotted fever rickettsiae into host endothelium." in: PLoS ONE, Vol. 12, Issue 8, pp. e0183181, (2017) (PubMed).
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- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
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别名
- FGFR1
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背景
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
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分子量
- 91868
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UniProt
- P11362
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins
抗原
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