-
- 抗原 See all TR4 (NR2C2) 抗体
- TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))
-
抗原表位
- AA 410-444, Ser439
-
适用
- 人, 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This TR4 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 预测反应
- Rat
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This TAK1 (Ser439) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 410-444 amino acids from human TAK1.
- 克隆位点
- RB56649
- 亚型
- Ig Fraction
- Top Product
- Discover our top product NR2C2 Primary Antibody
-
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (AA 560-600) antibody
NR2C2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (AA 43-152) antibodyNR2C2 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 2A5 unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (AA 62-356) antibodyNR2C2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 8F2E8 unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (pThr184), (pThr187) antibodyNR2C2 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (AA 240-380) antibodyNR2C2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (AA 1-530) antibodyNR2C2 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) antibodyNR2C2 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (pSer192) antibodyNR2C2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (AA 410-444), (pSer439) antibodyNR2C2 适用: 人 WB, IF 宿主: 兔 Polyclonal RB56649 unconjugated
anti-Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2) (AA 400-500) antibody (HRP)NR2C2 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal HRP
-
- 应用备注
- IF: 1:25. WB: 1:1000-1:2000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
-
- 抗原
- TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))
- 别名
- TAK1 (NR2C2 产品)
- 别名
- TAK1 antibody, TR2R1 antibody, TR4 antibody, hTAK1 antibody, Tr4 antibody, gb:dq017625 antibody, im:6911408 antibody, mKIAA4145 antibody, nuclear receptor subfamily 2 group C member 2 antibody, nuclear receptor subfamily 2, group C, member 2 antibody, NR2C2 antibody, Nr2c2 antibody, nr2c2 antibody
- 背景
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2- induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.
- 分子量
- 67196
- UniProt
- O43318
- 途径
- TCR Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades
-
You are here:
