FGFR3 抗体 (AA 449-482)
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Quick Overview for FGFR3 抗体 (AA 449-482) (ABIN6242233)
抗原
See all FGFR3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 449-482
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Mouse Fgfr3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 449-482 amino acids from the Central region of human Mouse Fgfr3.
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亚型
- Ig Fraction
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anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 529-694) antibody
FGFR3 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2H10B4 unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 166-375) antibodyFGFR3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 39-138) antibodyFGFR3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (N-Term) antibodyFGFR3 适用: 人, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 23-375) antibodyFGFR3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (C-Term) antibodyFGFR3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 529-694) antibodyFGFR3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1E3F9 unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) antibodyFGFR3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) antibodyFGFR3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB3380 unconjugated Recombinant Antibody
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) antibodyKD Validated FGFR3 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2965 unconjugated Recombinant Antibody
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
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别名
- Fgfr3
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背景
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of STAT1, STAT5A and STAT5B. Plays a role in postnatal lung development.
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分子量
- 87758
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UniProt
- Q61851
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
抗原
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