(1 reference)-
- 抗原 See all NCBP2 抗体
- NCBP2 (Nuclear Cap Binding Protein Subunit 2 (NCBP2))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NCBP2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 免疫原
- Synthetic Peptide
- Top Product
- Discover our top product NCBP2 Primary Antibody
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anti-Nuclear Cap Binding Protein Subunit 2 (NCBP2) (AA 1-156) antibody
NCBP2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 2 (NCBP2) antibodyNCBP2 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 2 (NCBP2) (AA 1-156) antibodyNCBP2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 2 (NCBP2) (N-Term) antibodyNCBP2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 2 (NCBP2) (N-Term) antibodyNCBP2 适用: 人, 小鼠, 大鼠, Cow, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 2 (NCBP2) (N-Term) antibodyNCBP2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 2 (NCBP2) (N-Term) antibodyNCBP2 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Cap Binding Protein Subunit 2 (NCBP2) (AA 1-99) antibodyNCBP2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 3A12 unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 储存条件
- 4 °C,-20 °C
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: "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay." in: Genes & development, Vol. 23, Issue 9, pp. 1091-105, (2009) (PubMed).
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: "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay." in: Genes & development, Vol. 23, Issue 9, pp. 1091-105, (2009) (PubMed).
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- 抗原
- NCBP2 (Nuclear Cap Binding Protein Subunit 2 (NCBP2))
- 别名
- NCBP2 (NCBP2 产品)
- 别名
- CBP20 antibody, CG12357 antibody, Dmel\\CG12357 antibody, 20kDa antibody, 5930413E18Rik antibody, AA536802 antibody, AI843301 antibody, C79367 antibody, CHUNP6917 antibody, zgc:92592 antibody, CBC2 antibody, NIP1 antibody, ATCBP20 antibody, CAP-binding protein 20 antibody, MLN1.12 antibody, MLN1_12 antibody, Ncbp2 antibody, cap binding protein 20 antibody, nuclear cap binding protein subunit 2 antibody, nuclear cap binding protein subunit 2, 20kDa antibody, nuclear cap binding protein subunit 2 L homeolog antibody, nuclear cap-binding protein subunit 2 antibody, CAP-binding protein 20 antibody, Nuclear cap-binding protein subunit 2 antibody, Cbp20 antibody, Ncbp2 antibody, ncbp2 antibody, NCBP2 antibody, ncbp2.L antibody, CBP20 antibody, ncbp-2 antibody
- 背景
- Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA- mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP2/CBP20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires NCBP1/CBP80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure.
- UniProt
- P52298
- 途径
- Ribonucleoprotein Complex Subunit Organization, Methionine Biosynthetic Process
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