Factor VIII 抗体
Our Local Distributor
北京 101111
Quick Overview for Factor VIII 抗体 (ABIN614478)
抗原
See all Factor VIII (F8) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
特异性
- This antibody recognizes full-length Human Factor VIII (F8). Does not cross-react with von Willebrand factor.
-
纯化方法
- Protein G chromatography
-
免疫原
- F8 antibody was raised against purified human Factor VIII.
-
亚型
- IgG1
-
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
浓度
- 0.73 mg/mL
-
缓冲液
- PBS, pH 7.4
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
储存方法
- Store the antibody at -20 °C to -70 °C.
-
-
- Factor VIII (F8) (Coagulation Factor VIII (F8))
-
背景
- This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.Synonyms: AHF, Antihemophilic factor, F8C, Procoagulant component
-
基因ID
- 2157
-
NCBI登录号
- NP_000123
-
UniProt
- P00451
抗原
-