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- 抗原 See all LAMTOR1 抗体
- LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))
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抗原表位
- AA 1-161
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This LAMTOR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
- 序列
- MGCCYSSENE DSDQDREERK LLLDPSSPPT KALNGAEPNY HSLPSARTDE QALLSSILAK TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT HWKKLPPLPS LTSQPHQVLA SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA KEELVVQFGI P
- 交叉反应
- 人, 小鼠, 大鼠
- 产品特性
- Polyclonal Antibodies
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 1-161 of human LAMTOR1 (NP_060377.1).
- 亚型
- IgG
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anti-Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1) (AA 2-161) antibody
LAMTOR1 适用: 人 IF, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:50 - 1:100
- 说明
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HIGH QUALITY
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- LAMTOR1 (Late Endosomal/lysosomal Adaptor, MAPK and mTOR Activator 1 (LAMTOR1))
- 别名
- LAMTOR1 (LAMTOR1 产品)
- 别名
- C11orf59 antibody, PDRO antibody, Ragulator1 antibody, p18 antibody, p27RF-Rho antibody, 2400001E08Rik antibody, Pdro antibody, C15H11orf59 antibody, c11orf59 antibody, flj20625 antibody, p27rf-rho antibody, pdro antibody, ragulator1 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 S homeolog antibody, LAMTOR1 antibody, Lamtor1 antibody, lamtor1.S antibody
- 背景
- As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.,LAMTOR1,C11orf59,PDRO,Ragulator1,p18,p27RF-Rho,Signal Transduction,Kinase,PI3K-Akt Signaling Pathway,Cell Biology & Developmental Biology,Autophagy,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,Cardiovascular,Lipids,Regulator of mTOR complex function,Regulators,LAMTOR1
- 分子量
- 17 kDa
- 基因ID
- 55004
- UniProt
- Q6IAA8
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