The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.,HSD17B4,DBP,MFE-2,MPF-2,PRLTS1,SDR8C1,Cancer,Tumor biomarkers,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cardiovascular,Lipids,Fatty Acids,HSD17B4