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SIAH2 抗体

SIAH2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5705475
发货至: 中国
  • 抗原 See all SIAH2 抗体
    SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
    适用
    • 37
    • 16
    • 15
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 35
    • 2
    克隆类型
    • 35
    • 2
    多克隆
    标记
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIAH2 antibody is un-conjugated
    应用范围
    • 24
    • 21
    • 20
    • 13
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    免疫原
    seven in absentia homolog 2 (Drosophila)
    亚型
    IgG
    Top Product
    Discover our top product SIAH2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze / thaw cycles.
    储存条件
    -20 °C
    有效期
    12 months
  • 抗原
    SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
    别名
    SIAH2 (SIAH2 产品)
    别名
    hSiah2 antibody, Xsiah-2 antibody, siah2-A antibody, xsiah2 antibody, AA415433 antibody, Sinh2 antibody, siah E3 ubiquitin protein ligase 2 antibody, siah E3 ubiquitin protein ligase 2 L homeolog antibody, seven in absentia 2 antibody, SIAH2 antibody, siah2.L antibody, Siah2 antibody
    背景
    Synonyms: Background:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation(POU2AF1, PML, NCOR1), a cell surface receptor(DCC), an antiapoptotic protein(BAG1), and a protein involved in synaptic vesicle function in neurons(SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.
    基因ID
    6478
    UniProt
    O43255
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