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SIAH2 产品

(Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008].

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Featured SIAH2 Categories

SIAH2 抗体

High quality antibodies with extensive validation data.

SIAH2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

SIAH2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SIAH2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
Cat. No. ABIN6265080
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7151218
Quantity 100 μg
Datasheet Datasheet
Reactivity Drosophila melanogaster, Human, Pig
Application IHC, FACS, IF, IHC (p), ICC, IHC (fro)
Validations
  • (2)
  • (2)
Cat. No. ABIN534023
Quantity 500 μL
Datasheet Datasheet

Recommended SIAH2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1131323
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1131324
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1131322
Quantity 96 tests
Datasheet Datasheet

Recommended SIAH2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319979
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319977
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3095363
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SIAH2 Products

Ma, Cheng, Mu, Geng, Zhao, Luo, Ma, Chang, Liu, Gao, Nie, Xie, Han, Chen, Ma, Zhu, Chen: "The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression." in: Nature communications, Vol. 10, Issue 1, pp. 1034, (2019) (PubMed).

Hughes, Hemenway, Guo, Yi, Yu, Hawley: "The E3 ubiquitin ligase Sina regulates the assembly and disassembly of the synaptonemal complex in Drosophila females." in: PLoS genetics, Vol. 15, Issue 5, pp. e1008161, (2019) (PubMed).

Jing, Nguyen, Wang, Pascal, Guo, Xu, Ai, Deng, Masoodi, Yu, Zhang, Nelson, Xia, Wang: "DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor." in: Oncogene, Vol. 37, Issue 5, pp. 638-650, (2018) (PubMed).

Ma, Cheng, Gao, Mu, Chen, Wu, Chen, Zhu: "Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways." in: Nature communications, Vol. 7, pp. 11123, (2016) (PubMed).

van der Willik, Timmermans, van Deurzen, Look, Reijm, van Zundert, Foekens, Trapman-Jansen, den Bakker, Westenend, Martens, Berns, Jansen: "SIAH2 protein expression in breast cancer is inversely related with ER status and outcome to tamoxifen therapy." in: American journal of cancer research, Vol. 6, Issue 2, pp. 270-84, (2016) (PubMed).

van Reesema, Zheleva, Winston, Jansen, OConnor, Isbell, Bian, Qin, Bassett, Hinson, Dorsch, Kirby, Van Sciver, Tang-Tan, Harden, Chang, Allen, Perry, Hoefer, Tang: "SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer." in: EBioMedicine, Vol. 11, pp. 183-198, (2016) (PubMed).

Tanaka, Li, Urata, Goto, Ono, Kawakatsu, Matsushima, Hirabaru, Adachi, Kitasato, Takatsuki, Kuroki, Eguchi: "Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma." in: Journal of gastroenterology, Vol. 50, Issue 9, pp. 975-83, (2015) (PubMed).

Qin, Smyrk, Reed, Schmidt, Schnelldorfer, Chari, Petersen, Tang: "Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1α pathway to predict survival in resectable pancreatic cancer." in: British journal of cancer, Vol. 112, Issue 3, pp. 514-22, (2015) (PubMed).

Moreno, Lara-Chica, Soler-Torronteras, Caro, Medina, Álvarez, Salvatierra, Muñoz, Calzado: "The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer." in: PLoS ONE, Vol. 10, Issue 11, pp. e0143376, (2015) (PubMed).

Wong, Chen, Liu, Parker, Möller: "Loss of Siah2 does not impact angiogenic potential of murine endothelial cells." in: Microvascular research, Vol. 102, pp. 38-45, (2015) (PubMed).

Synonyms and alternative names related to SIAH2

siah E3 ubiquitin protein ligase 2 (SIAH2), siah E3 ubiquitin protein ligase 2 L homeolog (siah2.L), seven in absentia 2 (Siah2), siah E3 ubiquitin protein ligase 2 (Siah2), AA415433, hSiah2, siah2-A, Sinh2, Xsiah-2, xsiah2

Protein level used designations for SIAH2

  • E3 ubiquitin-protein ligase SIAH2
  • seven in absentia homolog 2
  • siah-2
  • seven in absentia-like protein
  • E3 ubiquitin-protein ligase siah2
  • mSiah2
  • seven in absentia 2
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