Deltex Homolog 1 抗体
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- 抗原 See all Deltex Homolog 1 (DTX1) 抗体
- Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Deltex Homolog 1 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 免疫原
- deltex homolog 1 (Drosophila)
- 亚型
- IgG
- Top Product
- Discover our top product DTX1 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- Deltex Homolog 1 (DTX1) (E3 Ubiquitin-protein ligase DTX1 (DTX1))
- 别名
- DTX1 (DTX1 产品)
- 别名
- hDx-1 antibody, Fxit1 antibody, mKIAA4160 antibody, deltex antibody, dtx antibody, xdtx1 antibody, deltex E3 ubiquitin ligase 1 antibody, deltex homolog 1 (Drosophila) antibody, deltex 1, E3 ubiquitin ligase antibody, deltex 1 L homeolog antibody, deltex 1 S homeolog antibody, DTX1 antibody, dtx1 antibody, Dtx1 antibody, dtx1.L antibody, dtx1.S antibody
- 背景
- Synonyms: Background:Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity(By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB(Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.
- 分子量
- 67-72,58-63 kDa
- 基因ID
- 1840
- UniProt
- Q86Y01
- 途径
- Notch Signaling
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