NLRP1 抗体
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- 抗原 See all NLRP1 抗体
- NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NLRP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 免疫原
- NLR family, pyrin domain containing 1
- 亚型
- IgG
- Top Product
- Discover our top product NLRP1 Primary Antibody
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anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 1000-1100) antibody
NLRP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 589-655) antibodyNLRP1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 323-372) antibodyNLRP1 适用: 人, 小鼠, Cow, 犬, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (C-Term) antibodyNLRP1 适用: 人 WB, IHC, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 1-146) antibodyNLRP1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) antibodyNLRP1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 1-1429) antibodyNLRP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (AA 2-25), (N-Term) antibodyNLRP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (N-Term) antibodyNLRP1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, Pig, 兔, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-NLR Family, Pyrin Domain Containing 1 (NLRP1) (C-Term) antibodyNLRP1 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab05757( NLRP1 Antibody) at dilution of 1:1000
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))
- 别名
- NLRP1 (NLRP1 产品)
- 别名
- CARD7 antibody, CIDED antibody, CLR17.1 antibody, DEFCAP antibody, DEFCAP-L/S antibody, NAC antibody, NALP1 antibody, PP1044 antibody, SLEV1 antibody, VAMAS1 antibody, NLR family pyrin domain containing 1 antibody, NLRP1 antibody, Nlrp1 antibody
- 背景
- Synonyms:CARD7, CLR17.1, DEFCAP, DEFCAP L/S, DKFZp586O1822, KIAA0926, NAC, NALP1, NLRP1, PP1044, SLEV1, VAMAS1 Background:As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death(PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide(MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner(PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin(PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release(PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP(PubMed:17349957). Binds ATP(PubMed:11113115, PubMed:15212762).
- 分子量
- 160-166 kDa
- 基因ID
- 22861
- UniProt
- Q9C000
- 途径
- Positive Regulation of Endopeptidase Activity, Inflammasome
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