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OAS3 抗体

OAS3 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5696851
发货至: 中国
  • 抗原 See all OAS3 抗体
    OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))
    适用
    • 35
    • 16
    • 2
    宿主
    • 34
    • 1
    克隆类型
    • 35
    多克隆
    标记
    • 12
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    • 3
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    • 1
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    • 1
    • 1
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    This OAS3 antibody is un-conjugated
    应用范围
    • 30
    • 16
    • 13
    • 13
    • 4
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
    免疫原
    2'-5'-oligoadenylate synthetase 3, 100kDa
    亚型
    IgG
    Top Product
    Discover our top product OAS3 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    说明

    A375 cells were subjected to SDS PAGE followed by western blot with FNab05952(OAS3 antibody) at dilution of 1:800

    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide and 50 % glycerol  pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freeze / thaw cycles.
    储存条件
    -20 °C
    有效期
    12 months
  • 抗原
    OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))
    别名
    OAS3 (OAS3 产品)
    别名
    p100 antibody, Oasl10 antibody, 2'-5'-oligoadenylate synthetase 3 antibody, 2'-5' oligoadenylate synthetase 3 antibody, OAS3 antibody, Oas3 antibody
    背景
    Synonyms: Background:Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus(CHIKV), Dengue virus, Sindbis virus(SINV) and Semliki forest virus(SFV).
    分子量
    100 kDa
    基因ID
    4940
    UniProt
    Q9Y6K5
    途径
    Hepatitis C
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