OAS3 抗体
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- 抗原 See all OAS3 抗体
- OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This OAS3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)
- 免疫原
- 2'-5'-oligoadenylate synthetase 3, 100kDa
- 亚型
- IgG
- Top Product
- Discover our top product OAS3 Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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A375 cells were subjected to SDS PAGE followed by western blot with FNab05952(OAS3 antibody) at dilution of 1:800
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- OAS3 (2'-5' Oligoadenylate Synthetase 3 (OAS3))
- 别名
- OAS3 (OAS3 产品)
- 别名
- p100 antibody, Oasl10 antibody, 2'-5'-oligoadenylate synthetase 3 antibody, 2'-5' oligoadenylate synthetase 3 antibody, OAS3 antibody, Oas3 antibody
- 背景
- Synonyms: Background:Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L(RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus(CHIKV), Dengue virus, Sindbis virus(SINV) and Semliki forest virus(SFV).
- 分子量
- 100 kDa
- 基因ID
- 4940
- UniProt
- Q9Y6K5
- 途径
- Hepatitis C
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