MMP9 antibody is human, mouse and rat reactive. At least three isoforms of MMP9 are known to exist, this antibody only recognizes the two longest isoforms.
纯化方法
MMP9 Antibody is affinity chromatography purified via peptide column.
免疫原
MMP9 antibody was raised against a 16 amino acid peptide near the center of human MMP9.
The immunogen is located within amino acids 260 - 310 of MMP9 .
The matrix metalloproteinase (MMP) family are a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases (1). MMP9 degrades type IV and V collagens (2) and studies suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow (3) and plays a role in tumor-associated tissue remodeling (4).