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Caspase 8 抗体 (AA 221-225)

This anti-Caspase 8 antibody is a 兔多克隆 antibody detecting Caspase 8 in WB. Suitable for 人.

产品编号 ABIN5689547

发货至: 中国

Quick Overview for Caspase 8 抗体 (AA 221-225) (ABIN5689547)

抗原

See all Caspase 8 (CASP8) 抗体

Caspase 8 (CASP8)

适用

139
69
62
23
16
16
11
1
1

人

宿主

兔

克隆类型

多克隆

标记

101
17
11
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1

This Caspase 8 antibody is un-conjugated

应用范围

149
55
47
41
29
27
26
23
23
20
8
4
4
3
1
1
1
1

Western Blotting (WB)

Discover our top product CASP8 Primary Antibody

抗原表位
16

16

9

7

7

7

6

6

5

4

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 221-225

特异性

This antibody detects endogenous level of total Caspase8 protein.

纯化方法

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

免疫原

Caspase8 antibody was raised against a peptide sequence around aa.221~225 (T-L-D-K-V) derived from Human Caspase8.
anti-Caspase 8 (CASP8) (AA 411-482) antibody
CASP8 适用: 人, 小鼠, 大鼠, 猴, Pig, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 1-479) antibody
CASP8 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 188-280) antibody
CASP8 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 217-384) antibody
CASP8 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 7-201) antibody
CASP8 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 385-479) antibody
CASP8 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) antibody
CASP8 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1H11 unconjugated

anti-Caspase 8 (CASP8) (AA 410-449), (N-Term) antibody
CASP8 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) (AA 217-374) antibody
CASP8 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 8 (CASP8) antibody
CASP8 适用: 小鼠 WB, IHC, ELISA, ICC, FACS 宿主: 大鼠 Monoclonal 3B10 unconjugated

应用备注

Western Blot: 1:500~1:1000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store antibody at -20°C for up to one year.
抗原

Caspase 8 (CASP8)

别名

Caspase8

背景

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

分子量

18, 43, 57 kDa

基因ID

58022

NCBI登录号

NP_571585

UniProt

Q14790

途径

Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades

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