TNFSF14 抗体 (Extracellular Domain)
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- 抗原 See all TNFSF14 抗体
- TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))
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抗原表位
- Extracellular Domain
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TNFSF14 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- LIGHT Antibody is supplied as protein A purified IgG2b.
- 免疫原
- LIGHT antibody was raised against the extracellular domain of human LIGHT.
- 克隆位点
- 8D4
- 亚型
- IgG2b
- Top Product
- Discover our top product TNFSF14 Primary Antibody
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anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 62-240) antibody
TNFSF14 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 61-170) antibodyTNFSF14 适用: 人 WB, ELISA, IP, IHC (p) 宿主: 小鼠 Monoclonal 4E3 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 141-240) antibodyTNFSF14 适用: 小鼠, 大鼠 WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 51-239) antibodyTNFSF14 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 62-240) antibodyTNFSF14 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 1-239) antibodyTNFSF14 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (Internal Region) antibodyVerified TNFSF14 适用: 人 WB, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 58-239) antibodyTNFSF14 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14) (AA 1-204) antibodyTNFSF14 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- LIGHT antibody can be used for detection of CD80 by Western blot at 0.5 - 1 μ,g/mL. LIGHT antibody can be used for immunohistochemistry starting at 2 - 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- LIGHT Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- LIGHT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- TNFSF14 (Tumor Necrosis Factor (Ligand) Superfamily, Member 14 (TNFSF14))
- 别名
- LIGHT (TNFSF14 产品)
- 别名
- TNFSF14 antibody, CD258 antibody, HVEML antibody, LIGHT antibody, LTg antibody, TR2 antibody, HVEM-L antibody, Ly113 antibody, TNF superfamily member 14 antibody, tumor necrosis factor (ligand) superfamily, member 14 antibody, TNFSF14 antibody, Tnfsf14 antibody
- 背景
- LIGHT Antibody: LIGHT, also known as Tumor Necrosis Factor Superfamily member 14 (TNFSF14), is a co-stimulatory molecule that can regulate T-cell activation (1) and has recently been identified as an immune checkpoint protein. LIGHT binds to two different receptors, Herpes Virus Entry Mediator (HVEM) and Lymphotoxin beta Receptor (LTβR). While LIGHT binding to HVEM delivers a co-stimulatory signal to T cells (1), LIGHT binding to LTβR is critical for the formation of lymphoid structures which can stimulate T cell infiltration and activation of a tumor microenvironment, leading to rapid T cell-mediated tissue destruction (2). It has been shown that targeted delivery of LIGHT to tumors, thereby causing the T cell infiltration of the tumor, can enhance the response of the PD-1/PD-L1 checkpoint blockade anti-cancer therapy (3), suggesting that LIGHT may become a potent tool in anti-cancer treatment.
- 分子量
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Predicted: 26 kDa
- 基因ID
- 8740
- NCBI登录号
- NP_003798
- UniProt
- O43557
- 途径
- Cancer Immune Checkpoints
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