POLD1 抗体
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北京 101111
Quick Overview for POLD1 抗体 (ABIN567776)
抗原
See all POLD1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody reacts with DNA polymerase delta p125 catalytic subunit (125 kDa) by Western blotting.
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纯化方法
- Protein-G Agarose Chromatography of hybridoma supernatant.
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免疫原
- Recombinant full length His-Human p125.
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亚型
- IgG2a
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS, pH 7.2 containing 50 % Glycerol without preservatives.
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储存液
- Without preservative
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- Store the antibody (in aliquots) at -20 °C.
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- POLD1 (Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1))
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别名
- POLD1
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背景
- In eukaryotic cells, 3 types of DNA polymerases (pol), pol alpha, pol delta and pol epsilon function in accurate and efficient DNA replication. Pol delta is a heteromultimeric enzyme composed of a 125 kDa major catalytic subunit and three smaller accessory subunits. Pol delta requires a number of accessory molecules to exert its full activity. Proliferating cell nuclear antigen (PCNA) forms a doughnut-shaped trimer with a 35 Ä hole and works as the sliding clamp and replication factor C acts as the clamp loader to improve Pol delta processivity. Pol delta is also involved in nucleotide excision repair of DNA.Synonyms: DNA polymerase delta catalytic subunit, DNA polymerase subunit delta p125
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基因ID
- 5424
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NCBI登录号
- NP_002682
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UniProt
- P28340
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途径
- Telomere Maintenance, DNA Damage Repair, DNA Replication, Chromatin Binding, Synthesis of DNA
抗原
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