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c-MET 抗体 (AA 801-900)

This anti-c-MET antibody is a 兔多克隆 antibody detecting c-MET in WB 和 ELISA. Suitable for 小鼠.

Mouse Liver lysates probed with Met (c Met) Polyclonal Antibody, Unconjugated at 1:300 dilution and 4˚C overnight incubation. (c-MET 抗体 (AA 801-900))

1 image

产品编号 ABIN5675773

发货至: 中国

Quick Overview for c-MET 抗体 (AA 801-900) (ABIN5675773)

抗原

See all c-MET (MET) 抗体

c-MET (MET) (Met Proto-Oncogene (MET))

适用

225
130
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小鼠

宿主

兔

克隆类型

多克隆

标记

126
19
10
10
7
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7
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5
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This c-MET antibody is un-conjugated

应用范围

153
96
42
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9
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Western Blotting (WB), ELISA

Discover our top product MET Primary Antibody

抗原表位
41

28

27

24

12

12

9

7

7

7

5

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4

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3

3

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1
AA 801-900

交叉反应

小鼠

预测反应

Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human Met (c Met)

亚型

IgG
anti-Met Proto-Oncogene (MET) (AA 25-150) antibody
MET 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (AA 743-932) antibody
MET 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5E9C4 unconjugated

anti-Met Proto-Oncogene (MET) (AA 1092-1379) antibody
MET 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) antibody
MET 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Monoclonal 2D12 unconjugated Recombinant Antibody

anti-Met Proto-Oncogene (MET) (C-Term) antibody
MET 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (AA 743-932) antibody
MET 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5E9B7 unconjugated

anti-Met Proto-Oncogene (MET) (Internal Region) antibody
MET 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (Tyr1003) antibody
MET 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (AA 83-209) antibody
MET 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Met Proto-Oncogene (MET) (pTyr1349) antibody
MET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

c-MET (MET) (Met Proto-Oncogene (MET))

别名

Met (c Met)

背景

Synonyms: AUTS9, c met, cmet, c-Met, D249, Hepatocyte growth factor receptor, Hepatocyte growth factor receptor Precursor, HGF, HGF receptor, HGF SF receptor, HGF/SF receptor, HGFR, MET, Met proto oncogene tyrosine kinase, Met proto-oncogene (hepatocyte growth factor receptor), Met proto-oncogene, Met protooncogene, MET_HUMAN, Oncogene MET, Par4, Proto-oncogene c-Met, RCCP2, Renal cell carcinoma papillary 2 gene, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met.
Background: c-Met, a member of the tyrosine kinase superfamily, is the receptor for hepatocyte growth factor, also known as scatter factor (HGF/SF). The mature c-Met protein is a disulfide-linked heterodimer with Mr=190 kDa composed of a heavily glycosylated alpha subunit that is completely extracellular in localization, and a beta subunit comprising an extracellular ligand binding domain, a single transmembrane domain, and a cytoplasmic tyrosine kinase domain. Cells expressing c-Met include epithelial cells, endothelial cells, blood cells of various types, and glomerular mesenchymal cells. HGF/SF binding to c-Met stimulates receptor dimerization and the phosphorylation of numerous residues within the receptors cytoplasmic domain. Signaling proteins that are phosphorylated and/or localized in response to c-Met phosphorylation include: Grb2, Shc, Cbl, Crk, cortactin, paxillin, GAB1, PI3K, FAK, Src, Ras, ERK1 and 2, JNK, PLC gamma, AKT, and STAT3. HGF/SF stimulation of c-Met expressing cells enhances proliferation, migration, morphogenesis, and protease synthesis, characteristics that are associated with invasive cell phenotype. Many types of cancer exhibit sustained c-Met stimulation, overexpression, or mutation, including carcinomas of the colon, breast, ovary, lung, liver, prostate, thyroid, kidney, as well as melanomas and sarcomas. In addition to cancer studies, other research areas in which c-Met is under investigation include organogenesis, organ regeneration, angiogenesis and surgical wound healing.

基因ID

4233

UniProt

P08581

途径

RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor

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