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PARK7/DJ1 抗体

PARK7 适用: 小鼠, 大鼠 WB, IHC (p), ELISA (Capture) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5647859
发货至: 中国
  • 抗原 See all PARK7/DJ1 (PARK7) 抗体
    PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
    适用
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    小鼠, 大鼠
    宿主
    • 98
    • 15
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    • 1
    克隆类型
    • 93
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    多克隆
    标记
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    This PARK7/DJ1 antibody is un-conjugated
    应用范围
    • 96
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    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA (Capture)
    纯化方法
    Antigen affinity purified
    免疫原
    A recombinant mouse protein corresponding to amino acids A2-D189 was used as the immunogen for the DJ-1 antibody.
    亚型
    IgG
    Top Product
    Discover our top product PARK7 Primary Antibody
  • 应用备注
    Optimal dilution of the DJ-1 antibody should be determined by the researcher.\. Western Blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL,ELISA (Capture, recombinant mouse protein): 0.1-0.5 μg/mL (BSA-free format available)
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the DJ-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
    别名
    DJ-1 / Park7 (PARK7 产品)
    别名
    DJ-1 antibody, DJ1 antibody, CAP1 antibody, Dj1 antibody, SP22 antibody, dj1 antibody, zgc:103725 antibody, park7b antibody, park7 antibody, park7a antibody, Parkinsonism associated deglycase antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, parkinson protein 7 antibody, parkinson protein 7 S homeolog antibody, parkinson protein 7 L homeolog antibody, PARK7 antibody, Park7 antibody, park7 antibody, park7.S antibody, park7.L antibody
    背景
    Parkinson disease (autosomal recessive, early onset) 7, also known as DJ1, is a protein which in humans is encoded by the PARK7 gene. PARK7 belongs to the peptidase C56 family of proteins. PARK7 is mapped to chromosome 1p36. It acts as a positive regulator of androgen receptor-dependent transcription. It is also involved in tumorigenesis and in maintaining mitochondrial homeostasis. This gene may also function as a redox-sensitive chaperone, as a sensor foroxidative stress, and it apparently protects neurons against oxidative stress and cell death. It has been found that PARK7 mutations that impair transcriptional coactivator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease.
    UniProt
    Q99LX0
    途径
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
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