TLR5 抗体 (AA 261-420)
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- 抗原 See all TLR5 抗体
- TLR5 (Toll-Like Receptor 5 (TLR5))
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抗原表位
- AA 261-420
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TLR5 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Flow Cytometry (FACS)
- 特异性
- Recognizes human TLR5.
- 交叉反应
- 人
- 纯化方法
- Protein G purified.
- 免疫原
- Recombinant human TLR5 protein (aa 261-420).
- 克隆位点
- ABM22G1
- 亚型
- IgG2a
- Top Product
- Discover our top product TLR5 Primary Antibody
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anti-Toll-Like Receptor 5 (TLR5) (AA 325-644) antibody
TLR5 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 5 (TLR5) (AA 303-514) antibodyTLR5 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 5 (TLR5) (AA 693-858) antibodyTLR5 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 5 (TLR5) (AA 700-800) antibodyTLR5 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 小鼠 Monoclonal 19D759-2 unconjugated
anti-Toll-Like Receptor 5 (TLR5) (AA 693-858) antibodyTLR5 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C6 unconjugated
anti-Toll-Like Receptor 5 (TLR5) (AA 682-850) antibodyTLR5 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 5 (TLR5) (N-Term) antibodyTLR5 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 5 (TLR5) (AA 701-810) antibodyTLR5 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Like Receptor 5 (TLR5) (AA 517-634) antibodyTLR5 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1A11 unconjugated
anti-Toll-Like Receptor 5 (TLR5) (C-Term) antibodyTLR5 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- In PBS containing 0.05 % BSA and 0.05 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C. - 有效期
- 12 months
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- 抗原
- TLR5 (Toll-Like Receptor 5 (TLR5))
- 别名
- TLR5 (TLR5 产品)
- 别名
- SLEB1 antibody, TIL3 antibody, TLR-5 antibody, sleb1 antibody, til3 antibody, tlr-5 antibody, tlr5 antibody, toll like receptor 5 antibody, toll-like receptor 5 antibody, toll like receptor 5 L homeolog antibody, toll-like receptor 5b antibody, TLR5 antibody, Tlr5 antibody, tlr5.L antibody, tlr-5 antibody, tlr5b antibody
- 背景
- TLR5 (Toll-like Receptor 5) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR5 recognizes bacterial flagellin, a principal component of bacterial flagella and a virulence factor, via a conserved region within flagellin, the D1 portion/domain. Binding of flagellin induces the dimerization of TLR5, which in turn recruits MyD88. The recruitment of MyD88 leads to subsequent activation of IRAK4, IRAK1, TRAF6 and eventually IkappaB kinases. Activation of IkappaB kinases mobilizes the nuclear factor NF-kappaB and stimulates many downstream gene expressions, which initiate the canonical proinflammatory pathway, including TNF-alpha production. TLR5 may play a role in inflammatory bowel disease (IBD). Lower levels of TLR5 expression have been found in patients exhibiting moderate to severe ulcerative colitis (UC). TLR5 is suggested to be possibly involved in HPV induced inflammation and subsequent cervical neoplasia formation. It has been reported that TLR5 expression is detected in both ovarian epithelium and ovarian cancer cell lines, suggesting a possible role of TLR5 in inflammation induced ovarian cancer onset. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus and susceptibility to legionnaire disease, highlighting the importance of TLR5 in microbial recognition particularly at the mucosal surface.
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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