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HLA-B 抗体 (AA 241-362)

HLA-B 适用: 人 WB, ELISA, FACS, IHC, ICC 宿主: 小鼠 Monoclonal 2G7B10 unconjugated
产品编号 ABIN5542338
发货至: 中国
  • 抗原 See all HLA-B 抗体
    HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
    抗原表位
    • 11
    • 9
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 241-362
    适用
    • 93
    • 8
    • 8
    • 2
    宿主
    • 64
    • 27
    • 2
    小鼠
    克隆类型
    • 68
    • 25
    单克隆
    标记
    • 37
    • 15
    • 10
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-B antibody is un-conjugated
    应用范围
    • 53
    • 46
    • 27
    • 17
    • 16
    • 9
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    免疫原
    Purified recombinant fragment of human HLA-B (AA 241-362) expressed in E. Coli.
    克隆位点
    2G7B10
    亚型
    IgG1
    Top Product
    Discover our top product HLA-B Primary Antibody
  • 应用备注
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.05 % sodium azide
    储存条件
    4 °C,-20 °C
    储存方法
    4°C, -20°C for long term storage
  • 抗原
    HLA-B (Major Histocompatibility Complex, Class I, B (HLA-B))
    别名
    HLA-B (HLA-B 产品)
    别名
    AS antibody, HLAB antibody, SPDA1 antibody, mhc1b antibody, major histocompatibility complex, class I, B antibody, major histocompatibility complex nonclassical class Ib L homeolog antibody, HLA-B antibody, BOLA-B antibody, MAMU-B18 antibody, DKFZP469N1225 antibody, mhc1b.L antibody
    背景
    HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.,
    分子量
    58.8kDa
    HGNC
    4286
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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