DIABLO 抗体 (AA 56-239)
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北京 101111
Quick Overview for DIABLO 抗体 (AA 56-239) (ABIN5541224)
抗原
See all DIABLO 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 56-239
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纯化方法
- Protein-A affinity chromatography
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免疫原
- Recombinant human SMAC/Diablo (56-239aa) purified from E. coli
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亚型
- IgG2a
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应用备注
- The antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.Recommended starting dilution is 1:3000.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.4 containing 0.02 % Sodium Azide and 10 % Glycerol
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
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别名
- diablo,smac
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背景
- SMAC/Diablo is one of the proapoptotic proteins. SMAC promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. In healthy cells, SMAC is a mitochondrial protein, but when cells undergo apoptosis, SMAC is released into the cytosol. SMAC is ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes
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UniProt
- Q9NR28
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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