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SET/TAF-I 抗体 (N-Term)

Name: SET/TAF-I 抗体 (N-Term)
SKU: ABIN5535669
Availability: OutOfStock

This anti-SET/TAF-I antibody is a 兔多克隆 antibody detecting SET/TAF-I in WB 和 IHC (p). Suitable for 人.

SET Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. (SET/TAF-I 抗体 (N-Term))

IHC

Western blot analysis in Jurkat cell line lysates (35ug/lane). (SET/TAF-I 抗体 (N-Term))

2 images

产品编号 ABIN5535669

发货至: 中国

Quick Overview for SET/TAF-I 抗体 (N-Term) (ABIN5535669)

抗原

See all SET/TAF-I (SET) 抗体

SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

适用

人

宿主

兔

克隆类型

多克隆

标记

This SET/TAF-I antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Discover our top product SET Primary Antibody

抗原表位
7

6

6

3

2

2

2

1

1

1

1

1

1

1
AA 47-75, N-Term

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This SET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-75 amino acids from the N-terminal region of human SET.

亚型

Ig Fraction
anti-SET Nuclear Oncogene (SET) (N-Term) antibody
Verified SET 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 1-277) antibody
SET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 146-277) antibody
SET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人, 小鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 1-277) antibody
SET 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal M1-F5 unconjugated

anti-SET Nuclear Oncogene (SET) (N-Term) antibody
SET 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人, 小鼠, 大鼠 WB, FACS, ICC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 147-235) antibody
SET 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 35-84) antibody
SET 适用: 人, 小鼠, 大鼠, 小鸡, 非洲爪蟾, 斑马鱼, Cow, 马, 兔, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated

应用备注

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/mL

缓冲液

Supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原

SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

别名

SET

背景

Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher.

分子量

33 kDa

基因ID

6418

UniProt

Q01105

途径

Apoptosis