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- 抗原 See all PIP5K1A 抗体
- PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
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抗原表位
- AA 19-50, N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIP5K1A antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- 免疫原
- This PIP5K1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human PIP5K1A.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PIP5K1A Primary Antibody
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anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 1-500) antibody
PIP5K1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 293-562) antibodyPIP5K1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (N-Term) antibodyPIP5K1A 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 19-50), (N-Term) antibodyPIP5K1A 适用: 人 WB 宿主: 兔 Polyclonal RB01727 unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) antibodyPIP5K1A 适用: 人, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 258-347) antibodyPIP5K1A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- For WB starting dilution is: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 2 mg/mL
- 缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
- 别名
- PIP5K1A (PIP5K1A 产品)
- 别名
- Pip5k1b antibody, pip5k1c antibody, PIP5K1A antibody, pip5k1b antibody, Pipk5a antibody, Pipk5b antibody, pip5k1a antibody, zgc:110576 antibody, im:7140933 antibody, zgc:158838 antibody, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b antibody, PIP5K1A antibody, Pip5k1a antibody, pip5k1a.L antibody, pip5k1a antibody, pip5k1aa antibody, pip5k1ab antibody
- 背景
- Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP(2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P(4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis.
- 分子量
- 63 kDa
- 基因ID
- 8394
- UniProt
- Q99755
- 途径
- PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA
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