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- 抗原 See all PIP5K1A 抗体
- PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIP5K1A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 特异性
- PIP5K1A Antibody detects endogenous levels of total PIP5K1A.
- 预测反应
- Pig,Bovine,Sheep,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PIP5K1A, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PIP5K1A Primary Antibody
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anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 1-500) antibody
PIP5K1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 293-562) antibodyPIP5K1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 19-50), (N-Term) antibodyPIP5K1A 适用: 人 WB 宿主: 兔 Polyclonal RB01727 unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) antibodyPIP5K1A 适用: 人, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 258-347) antibodyPIP5K1A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
- 别名
- PIP5K1A (PIP5K1A 产品)
- 别名
- Pip5k1b antibody, pip5k1c antibody, PIP5K1A antibody, pip5k1b antibody, Pipk5a antibody, Pipk5b antibody, pip5k1a antibody, zgc:110576 antibody, im:7140933 antibody, zgc:158838 antibody, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b antibody, PIP5K1A antibody, Pip5k1a antibody, pip5k1a.L antibody, pip5k1a antibody, pip5k1aa antibody, pip5k1ab antibody
- 背景
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Description: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
Gene: PIP5K1A
- 分子量
- 62 kDa
- 基因ID
- 8394
- UniProt
- Q99755
- 途径
- PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA
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