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Insulin 抗体 (N-Term)

Name: Insulin 抗体 (N-Term)
SKU: ABIN5530710
Availability: OutOfStock

INS 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Western Blot at 1:2000 dilution + mouse liver lysate Lysates/proteins at 20 ug per lane. (Insulin 抗体 (N-Term))

Western Blot at 1:1000 dilution + 293 whole cell lysate Lysates/proteins at 20 ug per lane. (Insulin 抗体 (N-Term))

Western blot analysis of anti-INSR Pab in SK-BR-3 cell lysate (Insulin 抗体 (N-Term))

3 images

产品编号 ABIN5530710

发货至: 中国

Datasheet as PDF

抗原 See all Insulin (INS) 抗体

Insulin (INS)
抗原表位
16

9

9

8

7

3

3

2

2

1

1

1

1

1

1

1

1

1

1
AA 21-52, N-Term
适用
189

105

91

76

70

40

4

3

2

1

1

1

1

1

1

1

1

1
人, 小鼠
宿主
137

85

13

2

1

1
兔
Compatible Secondaries
克隆类型
144

97
多克隆
标记
120

20

15

8

5

5

5

5

5

5

4

4

4

4

4

4

3

3

3

3

3

3

2

2

1

1
This Insulin antibody is un-conjugated
应用范围
82

74

67

67

66

54

47

39

26

24

21

17

16

11

9

9

6

5

3

2

2

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This INSR(Insulin Receptor) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-52 amino acids from the N-terminal region of human INSR(Insulin Receptor).

亚型

Ig Fraction

Top Product

Discover our top product INS Primary Antibody
anti-Insulin (INS) (AA 1-110) antibody
INS 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin (INS) (AA 46-59) antibody
INS 适用: 小鼠, 大鼠 ELISA, WB, IHC (p), FACS, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Insulin (INS) antibody
INS 适用: 人 IHC, WB, IF 宿主: 兔 Monoclonal unconjugated

anti-Insulin (INS) (AA 90-110) antibody
INS 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin (INS) (AA 25-110) antibody
INS 适用: 大鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin (INS) antibody
INS 适用: 人, Pig, 小鼠, Cow, 大鼠, 兔, 豚鼠, 犬, 猴, Cat, 小鸡, 驴, 山羊, Hamster, 马, 绵羊, Avian WB 宿主: 山羊 Polyclonal unconjugated

anti-Insulin (INS) antibody
INS 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin (INS) (AA 25-110) antibody
INS 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin (INS) (AA 25-110) antibody
INS 适用: 人 IHC, WB, IP, ICC 宿主: 小鼠 Monoclonal H10 unconjugated

anti-Insulin (INS) (AA 25-54) antibody
INS 适用: Cow IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

For WB starting dilution is: 1:2000

For IHC-P starting dilution is: 1:50~100

限制

仅限研究用
状态

Liquid

浓度

0.42 mg/mL

缓冲液

Supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
抗原

Insulin (INS)

别名

INS (INS 产品)

别名

IDDM2 antibody, ILPR antibody, IRDN antibody, MODY10 antibody, ins1 antibody, xins antibody, ins1-a antibody, Insulin antibody, AA986540 antibody, Ins-2 antibody, InsII antibody, Mody antibody, Mody4 antibody, proinsulin antibody, zgc:109842 antibody, igf2-A antibody, ins antibody, ins-a antibody, ins-b antibody, insulin antibody, insulin precursor antibody, insulin II antibody, preproinsulin antibody, insulin L homeolog antibody, insulin S homeolog antibody, INS antibody, INS-IGF2 antibody, ins antibody, Ins antibody, PIN antibody, Ins2 antibody, ins.L antibody, ins.S antibody

背景

INSR is a receptor that binds insulin and has a tyrosine-protein kinase activity. Autophosphorylation activates the kinase activity. This Type I mebrane protein is composed of a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane. Defects in INSR are the cause of insulin resistance of various forms, including mild insulin-resistant diabetes mellitus with acanthosis nigricans, minor physical abnormalities and sometimes polycystic ovaries. Insulin resistance associated with acanthosis nigricans, hirsutism and hyperandrogenism is referred to as insulin resistance type A. Defects in INSR are the cause of Rabson-Mendenhall syndrome, also known as Mendenhall syndrome. It is a severe insulin resistance syndrome characterized by insulin-resistant diabetes mellitus with pineal hyperplasia and somatic abnormalities. Typical features include coarse, senile-appearing facies, dental and skin abnormalities, abdominal distension, and phallic enlargement. Inheritance is autosomal recessive. Defects in INSR are the cause of leprechaunism, also known as Donohue syndrome. Leprechaunism represents the most severe form of insulin resistance syndrome, characterized by intrauterine and postnatal growth retardation and death in early infancy. Inheritance is autosomal recessive. Defects in INSR may be associated with noninsulin-dependent diabetes mellitus.

分子量

156 kDa

基因ID

3643

UniProt

P06213

途径

NF-kappaB Signaling, RTK signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation