SNRPN 抗体 (N-Term)
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- 抗原 See all SNRPN 抗体
- SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SNRPN antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF
- 产品特性
- This is a rabbit polyclonal antibody against SMN. It was validated on Western Blot.
- 纯化方法
- Affinity purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human SMN
- Top Product
- Discover our top product SNRPN Primary Antibody
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anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (N-Term) antibody
SNRPN 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 46-95) antibodySNRPN 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 兔, 马, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 31-48), (N-Term) antibodySNRPN 适用: 人, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 1-240) antibodySNRPN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN) (AA 1-100) antibodySNRPN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N (SNRPN))
- 别名
- SMN (SNRPN 产品)
- 别名
- SNRB' antibody, SNRPB' antibody, Snrpn antibody, zgc:77315 antibody, HCERN3 antibody, PWCR antibody, RT-LI antibody, SM-D antibody, SMN antibody, SNRNP-N antibody, SNURF-SNRPN antibody, sm-N antibody, 2410045I01Rik antibody, Peg4 antibody, Pwcr1 antibody, FE 294 antibody, FE 294 psi antibody, FE294 antibody, FE294 psi antibody, SNURF antibody, SNRPN antibody, QflA-11237 antibody, QtrA-10022 antibody, Sm-N antibody, SmN antibody, snRNP-N antibody, small nuclear ribonucleoprotein polypeptide-like antibody, small nuclear ribonucleoprotein polypeptides B and B1 antibody, small nuclear ribonucleoprotein polypeptide N antibody, small nuclear ribonucleoprotein N antibody, small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51 antibody, SNRPN upstream reading frame antibody, Small nuclear ribonucleoprotein-associated protein N antibody, SNRPL antibody, snrpb antibody, SNRPN antibody, Snrpn antibody, snrpn antibody, SNURF antibody
- 背景
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This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy, mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.
Alias Symbols: SMN2, SMNC,
Protein Size: 294 - 基因ID
- 6606
- UniProt
- Q16637
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