RAD51 抗体 (C-Term)
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北京 101111
Quick Overview for RAD51 抗体 (C-Term) (ABIN5515418)
抗原
See all RAD51 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- DYSGRGELSA RQMHLARFLR MLLRLADEIV SEERKRGNQN LQNLRLSLSS
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产品特性
- This is a rabbit polyclonal antibody against RAD51. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human RAD51
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- RAD51 (DNA Repair Protein Homolog 1 (RAD51))
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别名
- RAD51
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背景
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The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: RAD51, RAD51A, RECA,
Protein Interaction Partner: BRCA1, ATRX, FBXO18, PALB2, HNRNPC, SWSAP1, HNRNPA2B1, RPA3, RPA1, RAD52, PFN1, RAD54B, AICDA, BLM, DMC1, NXF1, RECQL5, UGDH, CHEK1, BRCA2, SFR1, SWI5, NEDD8, PML, TERF2IP, TP53, MSH2, MSH6, UBC, UHRF2, RAD51AP1, WRN, POLN, MORF4L1, MDC1, RAD51C, MCPH1, S
Protein Size: 280 -
基因ID
- 5888
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途径
- DNA Damage Repair
抗原
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