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Lamin A/C 抗体 (C-Term)

This anti-Lamin A/C antibody is a 兔 多克隆 antibody detecting Lamin A/C in WB. Suitable for 人.
产品编号 ABIN5514925
发货至: 中国

Quick Overview for Lamin A/C 抗体 (C-Term) (ABIN5514925)

抗原

See all Lamin A/C (LMNA) 抗体
Lamin A/C (LMNA)

适用

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宿主

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克隆类型

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多克隆

标记

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This Lamin A/C antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    C-Term

    序列

    RTSGRVAVEE VDEEGKFVRL RNKSNEDQSM GNWQIKRQNG DDPLLTYRFP

    产品特性

    This is a rabbit polyclonal antibody against LMNA. It was validated on Western Blot.

    纯化方法

    Affinity purified

    免疫原

    The immunogen is a synthetic peptide directed towards the C-terminal region of Human LMNA
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原

    Lamin A/C (LMNA)

    别名

    LMNA

    背景

    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

    Alias Symbols: LMNA, LMN1,

    Protein Interaction Partner: LMNA, RAPGEF2, FUS, KRTAP10-3, KRTAP10-7, DUSP13, UBC, TP53, SUMO2, SUMO3, MDM2, EED, KIAA0196, ROCK2, ZW10, NCL, EEF1D, PSMD10, GMPPB, KPNA6, KCTD12, PARK2, FBXO6, YWHAQ, ZNF280C, PGRMC2, SCML2, HNRNPR, TRIM28, ZBTB33, NUP153, THRAP3, USP15, POM121, DDX4

    Protein Size: 664

    基因ID

    4000

    UniProt

    P02545

    途径

    Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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