Lamin A/C 抗体 (C-Term)
Quick Overview for Lamin A/C 抗体 (C-Term) (ABIN5514925)
抗原
See all Lamin A/C (LMNA) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- RTSGRVAVEE VDEEGKFVRL RNKSNEDQSM GNWQIKRQNG DDPLLTYRFP
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产品特性
- This is a rabbit polyclonal antibody against LMNA. It was validated on Western Blot.
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纯化方法
- Affinity purified
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human LMNA
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Lamin A/C (LMNA)
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别名
- LMNA
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背景
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The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Alias Symbols: LMNA, LMN1,
Protein Interaction Partner: LMNA, RAPGEF2, FUS, KRTAP10-3, KRTAP10-7, DUSP13, UBC, TP53, SUMO2, SUMO3, MDM2, EED, KIAA0196, ROCK2, ZW10, NCL, EEF1D, PSMD10, GMPPB, KPNA6, KCTD12, PARK2, FBXO6, YWHAQ, ZNF280C, PGRMC2, SCML2, HNRNPR, TRIM28, ZBTB33, NUP153, THRAP3, USP15, POM121, DDX4
Protein Size: 664 -
基因ID
- 4000
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UniProt
- P02545
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途径
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
抗原
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